Abstract Fibroblasts derived from the progeroid Werner syndrome show reduced replicative lifespan and a "stressed" morphology. both alleviated using the MAP kinase inhibitor SB203580. However. interpretation of these data is problematical because although SB203580 has the stress-activated kinases p38 and JNK1/2 as its preferred targets. https://www.bekindtopets.com/mega-sale-Israel-Flag-Distressed-iPhone-14-Pro-Max-Folio-Case-p26681-top-mega/